3 Prior infection with BA.1 appears to offer minimal cross-immunity to BA.2.12.1, thus people who had Omicron infection with BA.1 can also get infected with BA.2.12.1. The L452Q mutation had been previously observed in the Delta and Lambda variants and allows the virus to attach more tightly to the angiotensin-converting enzyme 2 receptor and thus become more transmissible. This subvariant has additional spike mutations S704L and L452Q on top of BA.2 background. As of May 25, 2022, about 58% of SARS-CoV-2 isolates sequenced were BA.2.12.1. In addition, many patients report gastrointestinal symptoms (eg, diarrhea, nausea, and vomiting) along with nonspecific symptoms (eg, muscle aches, headache, nasal congestion, and fatigue).įirst identified in New York, BA.2.12.1 is now the dominant variant in the US. The clinical manifestations of BA.2 infection are similar to those of BA.1, with mild upper respiratory symptoms (such as sore throat and pharyngitis) being common. 2 Its viral fitness is due to 53 mutations, 29 of which are in the spike protein. The BA.2 variant effective reproduction number is 1.4-fold higher than that of BA.1. 1 Since then, several lineages and sublineages have emerged. Shared Decision Making and CommunicationĪfter the Omicron variant (BA.1) was first identified in South Africa in November 2021, it quickly spread worldwide, outcompeting other variants and rapidly becoming the predominant variant in many countries including the US.Scientific Discovery and the Future of Medicine. ![]() Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience. ![]()
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